Kejadian Obat-Obatan Penginduksi Kerusakan Liver pada Pasien Sirosis Rawat Inap di RSUD Dokter Soedarso Kalimantan Barat

Robiyanto, Robiyanto and Liana, Jesica and Purwanti, Nera Umilia (2019) Kejadian Obat-Obatan Penginduksi Kerusakan Liver pada Pasien Sirosis Rawat Inap di RSUD Dokter Soedarso Kalimantan Barat. Jurnal Sains Farmasi & Klinis, 6 (3). pp. 274-285. ISSN 2407-7062

Preview

Text 390-1800-3-PB.pdf - Published Version Available under License Creative Commons Attribution Share Alike. Download (737kB) | Preview

Abstract

The potency of hepatotoxicity due to medication use is a risky clinical problem. This risk may aggravate the liver disease in a patient who already has a liver impairment condition. The aim of our research was to determine the most potential drug-induced liver injury (DILI) and the percentage of prescription drugs based on its Likelihood Score (category A,B,C,D,E,E*,X). This study was an observational descriptive with a cross-sectional design. Data retrieval was collected retrospectively using medical records of hospitalized cirrhosis patients in 2017. 36 patients who met inclusion criteria were involved as data sample. All data were analyzed using LiverTox database (https://livertox.nih.gov/) to categorize the Likelihood Score of each drug. The results of this study showed that the most prescribed drug which induce liver injury in cirrhosis patients were paracetamol (category A), ranitidine (B), cetirizine (C), spironolactone (D), furosemide (E), and ketorolac (E *). The percentage of prescription drugs for Likelihood Scores category A=1,7%; B=11,6%; C=0,4%; D=13,7%; E=23,6%; E*=3,4% and X=32,2%. It can be concluded that the prescription of drugs which potentially induced liver injury (category A. B. C. D. E. E*) in cirrhosis patients at Soedarso Provincial Hospital Pontianak is quite high (54.4%) and needs careful clinical consideration

Actions (login required)

View Item