Fabrikasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi sebagai Pembawa

Syukri, Yandi and Kholidah, Ziyyatul and Chabib, Lutfi (2020) Fabrikasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi sebagai Pembawa. Jurnal Sains Farmasi & Klinis, 6 (3). pp. 265-273. ISSN 2407-7062

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Abstract

Propolis is a poorly-water soluble resin produced by bees with antibacterial, antioxidant and anti-inflammatory activities. Self-nano emulsifying (SNE) is one of the drug delivery methods to improve drug solubility of poorly water-soluble. This study aimed to prepare a formulation of transparent and stable of propolis loading SNE with castor oil, cremophor RH40, and PEG 400 as the carriers. The preparation of SNE was conducted by mixing propolis with the vehicle. The spontaneous nanoemulsion area was constructed by the ternary phase diagram. The characterization includes particle size, zeta potential, transmittance, thermodynamic stability, robustness to dilution, and accelerated stability test. The nanoemulsion area was found in Formulae (F) 1 to F9 with a range composition of castor oil (10-30%), cremophor RH 40 (40-80%), and PEG 400 (10-40%). The nine formulas showed transmittance values at 96-99%, particle size 10-40 nm zeta potential less than -40 mV and stable during thermodynamic stability test. The accelerated stability test showed that F5 (20: 70: 10) produces the optimal SNE formula with no phase separation and precipitation. The transmittance was obtained between 97-99%, particle size in range 15-17 nm, polyiderpersity index value of 0,1-0,2. It can be concluded that SNE propolis with castor

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