Optimasi Nanoemulsi Natrium Askorbil Fosfat melalui Pendekatan Design of Experiment (Metode Box Behnken)

Nursal, Fith Khaira and Sumirtapura, Yeyet Cahyati and Suciati, Tri and Kartasasmita, Rahmana Emran (2019) Optimasi Nanoemulsi Natrium Askorbil Fosfat melalui Pendekatan Design of Experiment (Metode Box Behnken). Jurnal Sains Farmasi & Klinis, 6 (3). pp. 228-236. ISSN 2407-7062

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Abstract

The delivery system of active substance through the skin transcutaneously is limited due to the low bioavailability and difficulties to penetrate stratum corneum (SC) layer. Sodium ascorbyl phosphate (SAP) is a vitamin C derivative that is very hydrophilic and has a low permeability value. Like vitamin C, SAP can act as an antioxidant and also has anti-wrinkle activity because it can trigger the growth of collagen in fibroblasts. SAP was made in nanoemulsion preparation, because with a small globule size are expected to penetrate the SC layer and carry the active agent into the skin. Optimization of nanoemulsion formulations was carried out through a statistical design of experiment (DoE) approach consisting of factorial design and surface response methods (RSM) to obtain more effective and efficient results. Oil (VCO), surfactant (Tween 80), co-surfactant (PEG 400) composition and the process of stirring (time and speed) were the variables in the optimization of the formulation nanoemulsion. The parameters observed were globule size and polydispersity index. Determination of these factors by factorial 2 level design and followed by the Box Behnken method using Minitab software 17. The optimu conditions obtained were VCO 10%, surfactant combination 24%, stirring time 5 minutes and speed of stirring 200 rpm gave the result of globule size about 180 nm and polydispersity index below 0.5

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