Formulasi Dispersi Padat Pentagamavunon-0 (PGV-0) dalam Bentuk Sediaan Hidrogel dengan Kombinasi Basis Polimer Kitosan-Agar-PVP

Forestryana, Dyera and Ramadhan, Hafiz (2020) Formulasi Dispersi Padat Pentagamavunon-0 (PGV-0) dalam Bentuk Sediaan Hidrogel dengan Kombinasi Basis Polimer Kitosan-Agar-PVP. Jurnal Sains Farmasi & Klinis, 7 (1). pp. 67-75. ISSN 2407-7062

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Abstract

Pentagamavunon-0 (PGV-0) is a curcumin analogue which exhibit a better stability. PGV-0 has the antioxidant capacity, but undergoes first-pass metabolism when given via oral administration. To increase its effectiveness, PGV-0 is formulated into transdermal preparations. Due to its poor solubility in water, PGV-0 can be prepared into solid dispersion systems with polyvinylpyrrolidone (PVP) to enhance its solubility. This study aimed to formulate PGV-0/PVP solid dispersion into hydrogel matrix preparations. Three formulae using chitosan-agarose-PVP polymers as the bases were prepared by varying the amount of PVP. Evaluation is carried out on organoleptic properties, weight, thickness, pH, moisture content, moisture uptake, folding endurance, and drug content. In vitro penetration tests were carried out using Franz diffusion cells. The optimum formula of PGV-0/PVP 1:1 (F2B) solid dispersion hydrogel showed a moisture content of 1.2% ± 0.28% and flux value of 121.6227µg cm-² hour-¹

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