Biosintesis ZnO Nanopartikel dari Ekstrak Air Daun Jambu Biji (Psidium guajava L) dan Ion Zn2+ serta Interaksinya dengan Kitosan sebagai Antibakteri Escherichia coli

Fatoni, Ahmad and Hilma, Hilma and Rasyad, Ade Arinia and Novriyanti, Selly and Hidayati, Nurlisa (2020) Biosintesis ZnO Nanopartikel dari Ekstrak Air Daun Jambu Biji (Psidium guajava L) dan Ion Zn2+ serta Interaksinya dengan Kitosan sebagai Antibakteri Escherichia coli. Jurnal Sains Farmasi & Klinis, 7 (2). pp. 151-157. ISSN 2407-7062

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Abstract

The biosynthesis of ZnO nanoparticles and chitosan-ZnO nanoparticles has been carried out. The aims of this research were to modify and characterize of chitosan-ZnO nanoparticles and their application as an antibacterial agent of Escherichia coli. The characterization of chitosan-ZnO nanoparticles was conducted by FTIR spectroscopy and X-Ray diffractometer. ZnO nanoparticle was synthesized by the reaction between leaf extract of the common guava (Psidium guajava L) and zinc acetate dihydrate. Chitosan-ZnO nanoparticles were synthesized by the reaction between chitosan and ZnO nanoparticles. The agar diffusion method was used to study the antibacterial activity of chitosan-ZnO nanoparticles. The result showed that the wavenumber of FTIR spectra chitosan-ZnO nanoparticles appeared at 3427 cm−1. The crystalline size of ZnO nanoparticles was 16.54 nm. The average inhibition zone of chitosan-ZnO nanoparticles at concentration 10,000; 5,000; and 2.500 mg/L were 30.57 ± 0.87; 25.97 ± 1.42; and 23.10 ± 1.61 mm, respectively. The higher the concentration of chitosan-ZnO nanoparticles, the greater the inhibition zone.

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