Efek Fetotoksisitas Ekstrak Biji Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.)pada Mencit

Almahdy, A and Rika, Febrianti and Rusdi, Djamal (2008) Efek Fetotoksisitas Ekstrak Biji Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.)pada Mencit. Jurnal Sains dan Teknologi Farmasi.

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Abstract

In order to evaluate Phaleria macrocarpa (Scheff.) Boerl. (Mahkota Dewa) seed extract for possible embryo-fetotoxicity effects and disturbance of postnatal development of pups, female mice were treated on days 6-14 of pregnancy with either the extract (50, 100 and 200 mg/BW) or distilled water (1 ml/mouse), by gastric intubation. Half of the fetus was fixated in red alizarin for skeletal observation and the other half was soaked in Bouin solution. Fetals study suggest of embryo-fetotoxicity on the pups indicating that the seed may be not safe for mice on two higher doses 100 and 200 mg/kg BW. Keywords : fetotoxicity, Phaleria macrocarpa, mice

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi
Depositing User: Operator Repo Unand
Date Deposited: 30 Mar 2016 04:35
Last Modified: 30 Mar 2016 04:35
URI: http://repo.unand.ac.id/id/eprint/2021

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