Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) terhadap Fungsi Ginjal Tikus

Yuliandra, Yori and Armenia, Armenia and Salasa, Annisa Nur and Ismed, Friardi (2015) Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) terhadap Fungsi Ginjal Tikus. Jurnal Sains Farmasi & Klinis, 2 (1). pp. 54-59. ISSN 2407-7062

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Abstract

Sub-chronic toxicity test of the deffated ethanolic extract of Cassytha filiformis L. on the renal function of rat has been carried out. A number of 16 male rats aged 2-3 months, weighing ±250 g were used as experimental animals. The rats were divided into 4 groups which consisted of 1 control group and 3 extract-treated groups given 1.25, 2.5, and 5 mg/kg extract administrated intraperitoneally once a day for 14 days. The creatinine clearance, renal function, and the ratio of renal were calculated and analyzed by two-way ANOVA. The study showed that the creatinine clearance and renal function decreased significantly during treatment (p<0.05). The kidney weight ratio of groups treated with extract, especially with greater doses, showed a very significant increase as compared with control (p<0,01). These indicated that the ethanolic extract of C. filiformis on the doses of 1.25 – 5 mg/kg might decrease the renal function, althought it seemed to be relatively safe when used for 14 days.

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