PERBANDINGAN EFEKTIVITAS SERAT BENGKUANG (Pachyrhizus erosus) DALAM MENAGKAL PERKEMBANGAN OBESITAS DAN DIABETES MELLITUS PADA MENCIT PUTIH YANG DIINDUKSI DENGAN DUA JENIS PAKAN BERKALORI TINGGI

Santoso, Putra and Maliza, Rita (2019) PERBANDINGAN EFEKTIVITAS SERAT BENGKUANG (Pachyrhizus erosus) DALAM MENAGKAL PERKEMBANGAN OBESITAS DAN DIABETES MELLITUS PADA MENCIT PUTIH YANG DIINDUKSI DENGAN DUA JENIS PAKAN BERKALORI TINGGI. PROSIDING Seminar Nasional Biodiversitas dan Ekologi Tropika Indonesia Ke-5. pp. 121-132. ISSN 978-623-7736-84-4

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Abstract

Jicama (Pachyrhizus erosus, Fabaceae) is a potential source of dietary fiber eliciting various medicinal benefits. Our previous report revealed that isolated fiber of jicama tuber effectively prevents the development of obesity and diabetes mellitus in high-sucrose diet (HSD) fed mice. In this current study, we aimed to compare the effectivity of jicama fiber against the detrimental effect of HSD vs. high-fat diet (HFD). The jicama fiber was isolated by using the graded aqueous isolation method from the fresh tubers. Furthermore, as many as 25% (w/w) of fiber was supplemented in HSD (containing 30% sucrose; w/w) and HFD (containing 45% fat; w/w) and subsequently fed as diets for adult male albino mice ad libitum for 8 weeks (n = 12 for each diet type). At the end of treatment, we determined the body weight, epydidimal white adipose weight, random blood glucose and glucose tolerance. The results demonstrated that, under the HSD treatment, jicama fiber was more effective in counteracting the blood glucose increase (25.03% of suppression), and glucose intolerance (GTT-39: 25.40%), but less effective in suppressing the body weight increase (5.60%) and white adipose tissue increase (46.57%). Otherwise, under HFD treatment, jicama fiber was more effective in counteracting the body weight increase (19.82%) and adipose tissue increase (62.84%) but less effective in suppressing the random blood glucose increase (8.67%) and glucose intolerance (GTT-30: 13.22%). In conclusion, under the HFD, jicama fiber is more effective in preventing the development of obesity than diabetes mellitus, while under HSD, it is more effective in precluding the development of diabetes mellitus than obesity. This difference in effectivity should be considered in the further formulation and use of jicama fiber as diet supplement against metabolic diseases.

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