J.Natural Product Communications,2017,12(11):Chemical Constituents of Aglaia odorata Leaves and Their Anti-inflammatory Effects

Efdi, Mai (2017) J.Natural Product Communications,2017,12(11):Chemical Constituents of Aglaia odorata Leaves and Their Anti-inflammatory Effects. J.Natural Product Communications, 12 (11). pp. 1717-1720. ISSN 1934-578X (printed); 1555-9475 (online)

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Official URL: https://journals.sagepub.com/toc/npxa/12/11

Abstract

Aglaia odorata Lour. is a traditional herbal medicine belonging to the Meliaceae family. The aim of this study was to identify useful compounds for human health from A. odorata. Our phytochemical investigation resulted in the isolation of four constituents hesperetin-7,3'-O-dimethylether, 5α-dammar-20-ene�3,24,25-triol, odorine, and odorinol. All compounds suppressed LPS-induced TNF- expression in rat immortalized microglia HAPI cells; especially, hesperetin-7,3'-O-dimethylether showed most potent inhibitory effect. In addition, molecular docking analysis demonstrated that hesperetin-7,3'-O�dimethylether could be accommodated within hot spots of TNF- dimeric protein

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia
Depositing User: Mai Efdi
Date Deposited: 28 Sep 2021 03:28
Last Modified: 28 Sep 2021 03:28
URI: http://repo.unand.ac.id/id/eprint/43742

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