The Role of Angiopoietin-2 Gene Mutation on Clinical Severity of Dengue Disease in Children.

Mayetti, Mayetti Mayetti and Jamsari, Jamsari and Izzah, Amirah Zatil and Darwin, Eriyati and Somasetia, Dadang Hudaya The Role of Angiopoietin-2 Gene Mutation on Clinical Severity of Dengue Disease in Children. Open Access Macedonian Journal of Medical Sciences. ISSN 1857-9655

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Abstract

BACKGROUND: In general, angiopoietin-2 levels are increased concomitantly with dengue clinical severity. AIM: This research aims to determine the role of mutation on angiopoietin-2 on dengue clinical severity. METHODS: A cross-sectional study of 108 children with dengue disease grouped by severity. Angiopoietin-2 level was examined by enzyme-linked immunosorbent assay. Polymerase chain reaction and double nucleic acid sequencing are using 2 Exon 4-F primers. RESULTS: Angiopoietin-2 levels on rs7834131 mutant are higher in dengue fever (p < 0.05) and dengue hemorrhage fever group than non-mutant, while on dengue shock syndrome, it is lower than non-mutant. CONCLUSION: Angiopoietin-2 mutation on rs7834131 might have a protective effect on dengue disease severity.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > S3 Ilmu Biomedik
Depositing User: Mr Jamsari J
Date Deposited: 08 Feb 2021 00:48
Last Modified: 08 Feb 2021 00:48
URI: http://repo.unand.ac.id/id/eprint/37833

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