Pengaruh Komponen Hidrofobik Elastis terhadap Karakteristik Fisik dan Laju Disolusi Tablet Eritromisin Stearat

Paramita, Diajeng Putri and Setyawan, Dwi (2019) Pengaruh Komponen Hidrofobik Elastis terhadap Karakteristik Fisik dan Laju Disolusi Tablet Eritromisin Stearat. Jurnal Sains Farmasi & Klinis, 6 (3). pp. 220-227. ISSN 2407-7062

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Abstract

Erythromycin stearate (ERS) is known for sintering phenomena during compression that can impact the dissolution profile. ERS tablets were prepared in binary mixture with paracetamol (PRS) and mefenamic acid (ASM) to examine the effect of the last two hydrophobic characteristics toward sintering of ERS. Physical characterization was performed using mechanical strength test, X-ray powder diffraction (XRPD), scanning electron microscope (SEM), differential thermal analysis (DTA), infrared spectrophotometry, and dissolution test. Tensile strength of ERS tablet was improved in presence of PRS and ASM that better improvement was shown by ASM. Superimposition of diffraction pattern of ERS with PRS or ASM was observed on XRPD diffractogram of binary tablet. SEM photomicrographs displayed particle boundaries on the surface of binary tablet of ERS-PRS and ERS-ASM. Infrared spectra and DTA thermograms did not exhibit any new or different peak due to interaction between compounds except for polymorphic transformation of PRS exhibited by thermogram data. Improvement of dissolution profile was shown by ERS-PRS binary tablet compared to ERS tablet. According to the results, it can be concluded that PRS and ASM can minimize sintering phenomena of ERS, and it does not involve any specific interaction. However, only PRS can improve dissolution of ERS tablet

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