Profil distribusi dan eliminasi senyawa α-Mangostin setelah pemberian Oral pada Tikus.

Syamsudin, Syamsudin and Faridah, Faridah and Diah, Widowati and Faizatun, Faizatun (2008) Profil distribusi dan eliminasi senyawa α-Mangostin setelah pemberian Oral pada Tikus. Jurnal Sains dan Teknologi Farmasi, 13 (2).

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Abstract

A studi on α-Mangostin distribution profile using higt performance liquid chromatography (HPLC) method was conducted on several organ (heart, liver, kidneys, lungs and intestines) and secretion (feses and urine) of mice. The compound was administered orally to male mice with the dose of 20mg/kg body weight. The validation of the HPLC methode employed C-18 column, methanol moving phase and ultraviolet detector with λ 319 mn. The tested parameters were system apness test, linearity test, detection and quantitative limit test, precision test, accuration test of the α-Mangostin quantity in urine, feses, heart, liver, kidneys, intestines and lungs. Result showed that method validation met the requirements. The α-Mangostin distribution system profile at the 6th hour showed that highest amount was in the heart (9,12 µg/g) while the lowest amount was in the intestines (2,23 µg/g). The α-Mangostin elimination profile in the urine at the 12th hour was 0,75 bpj. While there was no trace of α-Mangostin the urine at the 24 th, 36 th, and 48 th hour. At the 12 th hour the quantity of α-Mangostin in the feses was 3,21 bpj, then it rose to 7,77 bpj at the 24 th. It decrease to 2.74 bpj at the 36 th hour and there was no trace at the 48 hour. Keyword: α-Mangostin, distribution profile, elimination profile.

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