UJI EFEK IMUNOSTIMULASI EKSTRAK ETANOL HERBA CIPLUKAN (Physalis angulata L.) TERHADAP AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG PADA MENCIT PUTIH BETINA

Aldi, Yufri and Aria, Mimi and Erman, Lusia (2014) UJI EFEK IMUNOSTIMULASI EKSTRAK ETANOL HERBA CIPLUKAN (Physalis angulata L.) TERHADAP AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG PADA MENCIT PUTIH BETINA. SCIENTIA JURNAL FARMASI DAN KESEHATAN, 4 (1). pp. 38-42. ISSN 2087-5045

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Abstract

This research investigated the immune stimulation affect of ethanol extract of ciplukan ( Physalis angulata L.) based on its affect on macrophages activities and capacities, leukocytes count, and relative weights of lymph. Twenty female mice were divided into 4 equal groups, the first control group (I) received Na CMC 0,5%, group II, III, IV received 100, 300, 500 mg ethanol extract/Kg BW which were administered orally for 7 days. On 8 th day, the leukocyte cells were counted, suspension of Staphylococcus aureus (SA) were injected intraperitoneally and then macrophages activities and capacities were counted, the weight of lymph was also measured. Result: at dose 100, 300, 500 mg ethanol extract of ciplukan/Kg BW was significantly affected the total of leukocytes (P<0,05), the macrophages activities and capacities and the relative weights of lymph was significantly affected (P<0,05). Keywords : Physalis angulata L., phagocytosis, macrophage, immune stimulating

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