Armenia, Armenia and Wattimena, Wattimena (2010) AKTIVITAS EKSTRAK ETANOL DAUN CONNARUS GRANDIS JACK. TERHADAP SISTIM SARAF PUSAT. JUMPA JURNAL MATEMATIKA DAN PENGETAHUAN ALAM.
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Other (AKTIVITAS EKSTRAK ETANOL DAUN CONNARUS GRANDIS JACK. TERHADAP SISTIM SARAF PUSAT.)
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Abstract
The central nervous system depressant activity of the ethanolic extract af Connarus grandis leaves has been evaluated by using the prolongrng sleeping time of barbiturat and anti convulsion methods. [n this study the ED50 of pentobarbital in mice was reduced by 10 mg/tg body weigh extract from 29.A6 to 23.18 m/kg.The extract prolonged the sleeping time of mice induced by several level doses of pentobarbital (p < 0.01) while the oncset of sleeping was not significantly affected (p>0.01). Connarus grandis leavese Kract was also protected mice from convulsion indued by 2 mgkg bw strychnine nitrate but not by 100 mdkg pentetrazol. The CPDstr 50 of 47.50 mdkg and the DPDstr 50 of K.1A m/kg. Thus, the ethanolic extract of Connants grandis leave acted upon the inhibitory nervous system mediatedby glycine.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi |
| Depositing User: | Operator Repo Unand |
| Date Deposited: | 30 Mar 2016 04:57 |
| Last Modified: | 30 Mar 2016 04:57 |
| URI: | http://repo.unand.ac.id/id/eprint/2054 |
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