Decreased Interleukin-4 Level of Type I Hypersensitive Mice Using Scopoloetin Isolated from Noni Fruit (Morinda citrifolia L.).

Aldi, Yufri and Yuliandra, Yori and Nasrul, Ellyza and Yanwirasti, Yanwirast and Handayani, Dian and Bakhtiar, Amri (2015) Decreased Interleukin-4 Level of Type I Hypersensitive Mice Using Scopoloetin Isolated from Noni Fruit (Morinda citrifolia L.). Research Journal of Pharmaceutical, Biological and Chemical Sciences.

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Abstract

An in vivo study of the activity of scopoletin isolated from noni fruit (Morinda citrifolia L.) on the level of interleukin-4 (IL-4) in type I hypersensitive male Swiss-Webster mice has been carried out. Scopoletin was isolated from dried noni powder by soxhletation method using dichloromethane, separated by column chromatography using silica gel as stationary phase and n-hexane-ethyl acetate (1:4) as mobile phase, then purified by column chromatography using Sephadex LH20 as stationary phase and methanol as mobile phase. Type I hypersensitive male mice were obtained by ovalbumin sensitization. Animal model were divided into 5 groups: negative control group, positive control group, and scopoletin-treated group (1; 3; and 10 mg/kg). The results showed that scopoletin at doses of 1, 3 and 10 mg/kg decreased the level o f IL-4 of type I hypersensitive mice significantly (p <0.01). The scopoletin at the dose of 10 mg/kg decreased the serum level of IL-4 to the normal level. Keywords: noni fruit, morinda citrifolia, scopoletin, type I hypersensitivity, interleukin-4

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