Mikroenkapsulasi Metformin Hidroklorida dengan Penyalut Etilsellulosa Menggunakan Metoda Penguapan Pelarut

Noviza, Deni and Harliana, Tita and Rasyad, Ade Arinia (2013) Mikroenkapsulasi Metformin Hidroklorida dengan Penyalut Etilsellulosa Menggunakan Metoda Penguapan Pelarut. Jurnal Sains dan Teknologi Farmasi.

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Abstract

Metformin hydrochloride is a biguanide class of oral antidiabetic drugs that have a half-life 1.5 to 3 hours, and it administration was repeated. In order to support the treatment of diabetic disease, metformin hydrochloride was made into microcapsules as a maintenance dose using solvent evaporation method using ethyl cellulose as a coated. The comparison between metformin hydrochloride and ethyl cellulose were 1: 0.75; 1: 1 and 1: 1.25. Microencapsulation evaluated by microscopic photograph, assay and dissolution test. At the microscopic picture shows metformin hydrochloride veiled by a layer of ethyl cellulose. The amount of metformin hydrochloride in F1 is 20.73%, 15.40% at FII and FIII is 10.11%. The biggest drug release inhibiton was achieved in formula 3 (1; 1.25) with dissolution efficiency was 0.170.

Item Type: Article
Subjects: R Medicine > RT Nursing
Divisions: Fakultas Farmasi
Depositing User: Operator Repo Unand
Date Deposited: 28 Mar 2016 07:50
Last Modified: 28 Mar 2016 07:50
URI: http://repo.unand.ac.id/id/eprint/1649

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